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Related Experiment Video

Updated: Jun 10, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

Fibromyalgia and fatigue: central processing, widespread dysfunction.

Patrick H Finan¹, Alex J Zautra

¹Department of Psychology, Arizona State University, 7001 Williams Field Road, Tempe, AZ 85287, USA.

PM & R : the Journal of Injury, Function, and Rehabilitation

|July 27, 2010

Summary

Fibromyalgia (FM) involves central sensitization, leading to pain and fatigue. Treatments, both medication and lifestyle changes, can effectively manage these core FM symptoms.

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A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

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Last Updated: Jun 10, 2026

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

A Randomized, Sham-Controlled Trial of Cranial Electrical Stimulation for Fibromyalgia Pain and Physical Function, Using Brain Imaging Biomarkers

Published on: January 5, 2024

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

A Rat Model of Central Fatigue Using a Modified Multiple Platform Method

Published on: August 14, 2018

Area of Science:

Neuroscience
Psychology
Rheumatology

Background:

Fibromyalgia (FM) is a complex chronic pain disorder.
Central sensitization is a key pathophysiological mechanism in FM.
Pain and fatigue are the most debilitating symptoms experienced by patients.

Purpose of the Study:

To review the biological and psychological underpinnings of the relationship between pain and fatigue in FM.
To discuss the impact of sleep disturbance and affective dysregulation on FM symptoms.
To highlight effective treatment strategies for FM.

Main Methods:

Literature review of biological and psychological factors.
Analysis of the interplay between pain, fatigue, sleep, and affect.
Synthesis of evidence on pharmacological and nonpharmacological interventions.

Main Results:

Central sensitization underlies the covariation of pain and fatigue in FM.
Sleep disturbance and affective dysregulation significantly influence FM symptoms.
Positive affective disturbance may be a unique feature of FM pain and fatigue.

Conclusions:

Understanding the biological and psychological factors is crucial for managing FM.
Integrated treatment approaches addressing pain, fatigue, sleep, and affect are most effective.
Pharmacological and nonpharmacological therapies show promise in alleviating FM symptoms.