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Related Experiment Video

Updated: Jun 10, 2026

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Published on: February 8, 2019

The Gonococcus fights back: is this time a knock out?

David A Lewis¹

¹STI Reference Centre, National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, Johannesburg, South Africa. davidl@nicd.ac.za

Sexually Transmitted Infections

|July 27, 2010

Summary

This summary is machine-generated.

Neisseria gonorrhoeae is rapidly evolving resistance to antibiotics, including cephalosporins, posing a significant global health threat. Urgent action is needed to strengthen public health systems and develop new strategies to combat untreatable gonorrhea.

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Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

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Metal-Limited Growth of Neisseria gonorrhoeae for Characterization of Metal-Responsive Genes and Metal Acquisition from Host Ligands

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Generation of Knock-out Primary and Expanded Human NK Cells Using Cas9 Ribonucleoproteins

Published on: June 14, 2018

Area of Science:

Microbiology
Public Health
Infectious Diseases

Background:

Neisseria gonorrhoeae has consistently developed resistance to antibiotics since the 1930s.
Sequential antibiotic classes, including penicillin, tetracyclines, spectinomycin, and fluoroquinolones, have faced diminishing efficacy due to acquired resistance.
The emergence of cephalosporin resistance in gonococci presents a critical global public health challenge.

Purpose of the Study:

To highlight the historical and current challenges posed by Neisseria gonorrhoeae antibiotic resistance.
To emphasize the urgent need for new antimicrobial agents and vaccine research.
To underscore the potential impact of untreatable gonorrhea on HIV transmission and the inadequacy of current STI control programs.

Main Methods:

This study is a review of the historical antibiotic resistance patterns of Neisseria gonorrhoeae.
Analysis of the timeline of resistance development against various antibiotic classes.
Assessment of the current global public health implications of emerging multidrug-resistant strains.

Main Results:

Neisseria gonorrhoeae has demonstrated a rapid ability to acquire genetic resistance determinants across multiple antibiotic classes.
Chromosomal resistance to fluoroquinolones emerged within a decade of their introduction.
Cephalosporin resistance is now a significant global concern, with a lack of new drug development and vaccine research.

Conclusions:

The global spread of multidrug-resistant Neisseria gonorrhoeae is a serious threat, exacerbated by weak public health systems and insufficient investment in new treatments.
Untreatable gonorrhea could significantly increase HIV transmission rates, particularly in high-prevalence areas.
Strengthening public health infrastructure and implementing novel strategies are crucial to prolong the effectiveness of existing antimicrobials and combat extensively drug-resistant gonorrhea.