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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: Jun 10, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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Epigenetics and child health: basic principles.

A Groom1, H R Elliott, N D Embleton

  • 1Institute for Ageing and Health, Newcastle University, Newcastle-upon-Tyne, UK.

Archives of Disease in Childhood
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Early life epigenetics influences health, development, and aging. Environmental factors impact these epigenetic patterns, affecting gene function and child health outcomes.

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Last Updated: Jun 10, 2026

Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
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Area of Science:

  • Epigenetics and developmental biology
  • Environmental health sciences

Background:

  • Epigenetic mechanisms are crucial in disease, development, and aging.
  • Early life is a period of significant epigenomic plasticity.

Purpose of the Study:

  • To review the determinants of epigenetic patterns.
  • To explore the environmental influences on epigenetics.
  • To highlight the relevance of epigenetics to child health.

Main Methods:

  • Literature review of epigenetic research.
  • Synthesis of evidence on environmental-epigenetic interactions.
  • Analysis of epigenetic impacts on gene function.

Main Results:

  • Epigenetic patterns are shaped by environmental exposures.
  • Epigenetic modifications influence gene expression.
  • These mechanisms have implications for child health.

Conclusions:

  • Understanding epigenetic determinants is vital for child health.
  • Early life epigenomic plasticity offers intervention opportunities.
  • Environmental factors play a key role in shaping health trajectories.