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Related Concept Videos

Introduction to Cytoskeleton01:33

Introduction to Cytoskeleton

Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments ̶   microfilaments, microtubules, and intermediate filaments. Each has characteristic features that distinguish them, including the dynamics of their assembly and disassembly, mechanical properties, polarity, and the type of molecular motors associated with them. Earlier, they were thought to be present only in eukaryotic cells; however, their homologs were...
Studying the Cytoskeleton01:17

Studying the Cytoskeleton

The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
Introduction to the Cytoskeleton01:33

Introduction to the Cytoskeleton

Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments ̶   microfilaments, microtubules, and intermediate filaments. Each has characteristic features that distinguish them, including the dynamics of their assembly and disassembly, mechanical properties, polarity, and the type of molecular motors associated with them. Earlier, they were thought to be present only in eukaryotic cells; however, their homologs were...
Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...

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Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling
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Published on: November 17, 2019

Cytoscape Web: an interactive web-based network browser.

Christian T Lopes1, Max Franz, Farzana Kazi

  • 1Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.

Bioinformatics (Oxford, England)
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Cytoscape Web is an open-source, web-based network visualization tool. It offers interactive and customizable features for easy website integration and supports multiple data file formats.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Network Science

Background:

  • Network visualization is crucial for understanding complex biological systems.
  • Existing tools may lack web-based accessibility and ease of integration.
  • Cytoscape is a widely used desktop application for network analysis.

Purpose of the Study:

  • To introduce Cytoscape Web, a novel web-based network visualization tool.
  • To provide an interactive and customizable platform for biological network exploration.
  • To facilitate the integration of network visualization into existing websites.

Main Methods:

  • Cytoscape Web is developed using Flex/ActionScript.
  • It features a JavaScript API for seamless web integration.
  • Supports data import via standard formats like GraphML, XGMML, and SIF.

Main Results:

  • Cytoscape Web provides an open-source, interactive, and customizable network visualization solution.
  • The tool is easily integrated into websites, enhancing accessibility.
  • Multiple data file exchange formats are supported for flexible data loading.

Conclusions:

  • Cytoscape Web offers a powerful and accessible platform for web-based network visualization.
  • Its flexibility and ease of integration make it a valuable tool for researchers and developers.
  • The tool democratizes network analysis by bringing it to the web.