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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

Updated: Jun 10, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Emerging interface between metabolic syndrome and asthma.

Anurag Agrawal1, Ulaganathan Mabalirajan, Tanveer Ahmad

  • 1Centre for Translational Research in Asthma & Lung disease, Institute of Genomics & Integrative Biology, Delhi, India. a.agrawal@igib.in

American Journal of Respiratory Cell and Molecular Biology
|July 27, 2010
PubMed
Summary

Obesity is linked to asthma, with metabolic factors like insulin resistance playing a key role. Targeting metabolic pathways may offer new asthma treatments.

Related Experiment Videos

Last Updated: Jun 10, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Area of Science:

  • Pulmonary Medicine
  • Metabolic Disorders
  • Immunology

Background:

  • Epidemiological data indicate a strong association between obesity and increased asthma risk.
  • Metabolic syndrome and insulin resistance are identified as significant risk factors for asthma, sometimes more so than body mass index.
  • The obese-asthma subphenotype is characterized by minimal inflammation, severe symptoms, poor response to glucocorticoids, and peripheral airway dysfunction.

Purpose of the Study:

  • To review the mechanistic links between obesity and asthma.
  • To emphasize the role of metabolic abnormalities in asthmatic processes.
  • To discuss potential therapeutic implications and challenges.

Main Methods:

  • Review of epidemiological evidence linking obesity and asthma.
  • Analysis of studies on metabolic factors (hyperglycemia, hyperinsulinemia, insulin-like growth factors) influencing airway function.
  • Examination of research on nitric oxide-arginine metabolism and oxonitrosative stress in asthma models.

Main Results:

  • Obesity's link to asthma involves mechanisms beyond Th2 inflammation, including metabolic influences.
  • Hyperglycemia, hyperinsulinemia, and insulin-like growth factors impact airway structure and function.
  • Abnormalities in nitric oxide-arginine metabolism and oxonitrosative stress are implicated in obesity-associated asthma.

Conclusions:

  • Metabolic syndrome features may bridge obesity and asthma, offering therapeutic targets.
  • Experimental therapies targeting metabolic pathways (e.g., l-arginine, statins, arginase inhibitors) show promise but require clinical translation.
  • Understanding these links is crucial for developing novel treatments for the obese-asthma subphenotype.