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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jun 10, 2026

Studying TGF-&#946; Signaling and TGF-&#946;-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

TGF-beta1 interactome: metastasis and beyond.

M Perera1, C S Tsang, R J Distel

  • 1University of Hong Kong, Hong Kong.

Cancer Genomics & Proteomics
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Transforming growth factor-beta1 (TGF-beta1) drives cancer metastasis. Mapping its complex interactions reveals how TGF-beta1

More Related Videos

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Related Experiment Videos

Last Updated: Jun 10, 2026

Studying TGF-&#946; Signaling and TGF-&#946;-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

Experimental Metastasis Assay
08:28

Experimental Metastasis Assay

Published on: August 24, 2010

Area of Science:

  • Oncology and Molecular Biology
  • Cancer Research
  • Proteomics and Genomics

Background:

  • Transforming growth factor-beta1 (TGF-beta1) is a key cytokine with dual roles in cancer, acting as both a tumor suppressor and a potent inducer of metastasis.
  • Understanding the regulatory mechanisms of TGF-beta1 is crucial for developing effective cancer therapies.

Purpose of the Study:

  • To present an initial functional interactomic map of TGF-beta1.
  • To elucidate the role of TGF-beta1 interactome dynamics in regulating tumor progression and metastasis.
  • To highlight the potential of TGF-beta1 interactomic nodes for biomarker discovery and personalized cancer therapeutics.

Main Methods:

  • High-throughput proteomic and genomic data analysis.
  • Functional interactomic mapping of TGF-beta1.
  • Analysis of differential expression profiles of interactomic nodes.

Main Results:

  • TGF-beta1's metastatic-inducing properties are linked to its interactome.
  • Changes in the polarity of the TGF-beta1 interactome influence its contrasting effects on tumors.
  • Differential expression of key interactomic nodes drives these polarity shifts.

Conclusions:

  • The TGF-beta1 interactome plays a critical role in cancer progression and metastasis.
  • Mapping the TGF-beta1 interactome offers insights into developing novel cancer biomarkers.
  • Comprehensive and individualized TGF-beta1 interactome mapping is essential for personalized cancer therapy development.