Increase in renal phorbol ester receptors in rats with cyclosporine A-induced nephrotoxicity

Treatment of rats with cyclosporine A (50 mg/kg i.p.) for 4 days resulted in the impairment of renal function. Renal membrane and soluble phorbol ester receptor densities were significantly higher in cyclosporine A-treated rats compared to vehicle-treated rats. These data suggest that increased phorbol ester receptor (protein kinase C) may be involved in the increased renal vascular resistance associated with cyclosporine A-induced nephrotoxicity.