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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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The Retinoblastoma Gene01:20

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Multipotency of Hematopoietic Stem Cells

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Updated: Jun 10, 2026

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
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Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

Multicentric reticulohistiocytosis.

Arvind Kaul1, Sunil N Tolat, Vasudha Belgaumkar

  • 1Department of Dermatology, Sassoon Hospital, Pune-1, Maharashtra, India. arvindkaul16@gmail.com

Indian Journal of Dermatology, Venereology and Leprology
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Multicentric reticulohistiocytosis is a rare condition causing joint pain and skin lesions. Effective treatment involves bisphosphonates, steroids, and methotrexate for symptom relief.

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Area of Science:

  • Rheumatology
  • Dermatology
  • Pathology

Background:

  • Multicentric reticulohistiocytosis (MRH) is a rare, non-Langerhans cell histiocytosis.
  • MRH can present with systemic symptoms including arthritis and skin manifestations.

Observation:

  • A 50-year-old male presented with an 8-month history of fever, arthralgia, and cutaneous lesions.
  • Physical examination revealed papules, nodules, joint swelling (knees, elbows), and distal interphalangeal joint flexion deformities.
  • Laboratory findings included anemia and elevated erythrocyte sedimentation rate (ESR).

Findings:

  • Histopathological examination confirmed the diagnosis of multicentric reticulohistiocytosis.
  • The patient demonstrated a positive clinical response to treatment.

Implications:

  • Early diagnosis and multimodal treatment are crucial for managing MRH.
  • Combination therapy with bisphosphonates, systemic steroids, and methotrexate shows efficacy in MRH treatment.
  • Further research into the pathogenesis and optimal management strategies for MRH is warranted.