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Updated: Jun 10, 2026

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Preparation and physicochemical properties of the complex of naringenin with hydroxypropyl-beta-cyclodextrin
Jiping Wen1, Benguo Liu, Erdong Yuan
1College of Grain and Food, Henan University of Technology, Zhengzhou 450052, China. wjp1380@163.com
Abstract:
In this study a complex of naringenin with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) was prepared to improve the hydrophilicity of naringenin. The physicochemical properties of the complex were analyzed by ultraviolet-visible spectrometry (UV), infrared spectrometry (IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC). The result showed that naringenin had been molecularly dispersed in the HP-beta-CD matrix, not forming a new compound and HPLC analysis showed that the solubility of naringenin in water was enhanced from 4.38 microg/mL to 1,272.31 microg/mL.

