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Nautilus survey on chronic venous diseases
G B Agus1, A Jawien, F Carelli
1Section of Vascular Surgery and Angiology, Department of Specialist Surgical Sciences, University of Milan, Milan, Italy. giovanni.agus@unimi.it
Panminerva Medica
|July 27, 2010
Summary
Chronic venous disease (CVD) affects adults and aging individuals, with women being more prevalent. Key factors include pregnancies in adults, prolonged standing in younger individuals, and increasing age-related risks like obesity and previous thromboses.
Area of Science:
- Vascular Medicine
- Epidemiology
- Public Health
Background:
- Chronic venous disease (CVD) is a widespread condition confirmed by numerous epidemiological studies.
- General practitioners (GPs) are the primary point of contact for patients with suspected CVD.
- The Italian Project Nautilus aimed to assess CVD prevalence and risk factors using the CEAP classification.
Purpose of the Study:
- To investigate the determining factors associated with the onset and progression of CVD across different age groups.
- To utilize the CEAP classification criteria for a comprehensive evaluation of CVD.
- To provide data for optimizing preventive and treatment strategies for CVD.
Main Methods:
- A survey involving over 1000 GPs across Italy.
- Collection of anamnestic and clinical data from over 10,000 patients diagnosed with CVD.
- Categorization of patients into three age segments: ≤30 years, 31-60 years, and >60 years.
- Statistical evaluation of 83% of the collected patient data.
Main Results:
- CVD predominantly affects adult and aging populations, with women comprising four out of five cases.
- Pregnancy is a primary risk factor in adults, while prolonged standing is significant in younger individuals.
- Risk factors such as excess weight and history of superficial (SVT) or deep vein thrombosis (DVT) increase with age.
- Severe CVD signs (edema, venous ulcers) and inflammatory endothelial activation are more prevalent in older age groups.
- Previous SVT or DVT episodes are critical determinants for severe CVD (CEAP C4-C6), affecting over 50% of patients with a history compared to 20% without.
- Diabetes is associated with more severe CVD signs in 50% of patients.
Conclusions:
- The Nautilus Survey identified key factors influencing CVD development and progression across age segments.
- These factors are clinically significant for understanding CVD evolution.
- The findings support the development of tailored preventive and treatment approaches based on current pathophysiological understanding.
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