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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

Updated: Jun 10, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Genome-scale DNA methylation analysis.

Shaun D Fouse1, Raman O Nagarajan, Joseph F Costello

  • 1Brain Tumor Research Center, Department of Neurosurgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, CA 94158, USA. nagarajanr@cc.ucsf.edu

Epigenomics
|July 27, 2010
PubMed
Summary
This summary is machine-generated.

Mapping the human DNA methylome is in its early stages, with less than 1% of CpGs assessed. New genome-scale platforms like next-generation sequencing offer significant discovery potential for understanding DNA methylation and its role in health and disease.

Keywords:
DNA methylationMREMeDIPRRBSmethylation-sensitive restriction enzymemicroarraynext-generation sequencingreduced representation bisulfite sequencing

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Targeted DNA Methylation Analysis by Next-generation Sequencing

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Last Updated: Jun 10, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

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Published on: September 18, 2020

DNA Methylation: Bisulphite Modification and Analysis
12:34

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Published on: October 21, 2011

Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

Area of Science:

  • Genomics
  • Epigenetics
  • Molecular Biology

Background:

  • The human genome has millions of CpGs, forming the DNA methylome.
  • DNA methylation influences gene expression, chromatin structure, and is heritable.
  • Environmental factors and diet can alter DNA methylation, potentially causing disease.

Purpose of the Study:

  • To review current DNA methylation detection reagents and platforms.
  • To compare emerging microarray and sequencing technologies for methylome mapping.
  • To highlight the need for international coordination in methylome mapping.

Main Methods:

  • Review of methylation detection reagents.
  • Application of reagents to microarray and sequencing platforms.
  • Comparison of platform complexity, coverage, and precision.

Main Results:

  • Current methylome mapping techniques are in their formative stages.
  • Oligonucleotide arrays and next-generation sequencing show significant discovery potential.
  • Less than 1% of CpGs have been assessed in normal and disease methylomes.

Conclusions:

  • Standardization of methylome platforms is essential for comprehensive mapping.
  • International collaboration is needed to create a repository of methylome maps.
  • Further research using advanced platforms will uncover the full potential of the DNA methylome.