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The Merkel cell in oral human mucosa
Journal of Dental Research
|November 1, 1977
Summary
This study examined mucosal Merkel cells, revealing unique structures like intranuclear rodlets and Merkel granules. These cells exhibit neuronal and amine-storage properties, closely interacting with nerve axons.
Area of Science:
- Dermatology
- Neuroscience
- Cell Biology
Background:
- Merkel cells are intraepithelial cells found in the skin and mucosa.
- Their precise function and cellular characteristics are areas of ongoing research.
- Previous studies suggest Merkel cells possess features of both neurons and endocrine cells.
Purpose of the Study:
- To investigate the ultrastructural features of mucosal Merkel cells.
- To elucidate the relationship between Merkel cells and nerve axons in the mucosa.
- To further characterize the cellular qualities of Merkel cells.
Main Methods:
- Analysis of mucosal Merkel cells obtained from 10 patients.
- High-resolution microscopy to examine cellular ultrastructure.
- Immunohistochemical staining to assess cellular markers and relationships.
Main Results:
- Mucosal Merkel cells displayed characteristic features including intranuclear rodlets, clear cell qualities, fine desmosomes, and membrane-bound Merkel granules.
- Cellular "horns" were observed, indicating specialized cell-cell interactions.
- A close anatomical relationship between Merkel cells and terminal axons was confirmed.
Conclusions:
- Mucosal Merkel cells possess a unique combination of neuronal and amine-storage cell characteristics.
- The observed ultrastructural features support a sensory or neuroendocrine role for these cells.
- The close association with axons suggests a role in neuro-immuno-cutaneous interactions.