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Fatality in paraquat poisoning.

A M Sabzghabaee¹, N Eizadi-Mood, K Montazeri

¹Isfahan Clinical Toxicology Research Centre, Noor and Ali-Asghar General Teaching Hospital, Isfahan, Iran.

Singapore Medical Journal

|July 27, 2010

Summary

Acute paraquat (PQ) poisoning is a significant public health issue. High PQ intake, vomiting, and older age are linked to increased fatality in PQ poisoning cases.

Area of Science:

Toxicology
Public Health
Emergency Medicine

Background:

Acute paraquat (PQ) poisoning presents a major public health challenge, particularly in developing nations.
This study addresses the critical need to understand factors influencing outcomes in PQ poisoning.

Purpose of the Study:

To evaluate clinical data from acute paraquat poisoning cases.
To compare variables between survivors and non-survivors of paraquat poisoning.

Main Methods:

Retrospective evaluation of 29 patients admitted to a poisoning emergency department over five years.
Comparison of demographic data, PQ ingestion amount, time to admission/treatment, vomiting, and hospital stay between survivors and non-survivors.

Main Results:

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The in-hospital fatality rate was 55.2%.
Significant correlations were found between patient outcomes and vomiting (p=0.05) and age (p=0.013).
Ingesting over 40 mg/kg of 20% PQ was noted in most non-survivors (62.5%).

Conclusions:

Large paraquat ingestion volume, presence of vomiting, and advanced age are critical factors associated with high fatality rates in PQ poisoning.
These variables are crucial for assessing prognosis and managing paraquat poisoning cases.