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Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
Ocular involvement in patients with primary CNS lymphoma
Jung Taeck Hong1, Ju Byung Chae, Joo Yong Lee
1Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, 388-1 Pungnap-2-dong, Songpa-gu, Seoul 138-736, Korea.
Journal of Neuro-Oncology
|July 27, 2010
Summary
Primary CNS lymphoma (PCNSL) with ocular involvement affects nearly a third of patients, with ocular symptoms sometimes preceding neurological ones. Early detection and treatment of intraocular lymphoma can improve visual outcomes.
Area of Science:
- Ophthalmology
- Neurology
- Oncology
Background:
- Primary CNS lymphoma (PCNSL) is a rare malignancy.
- Ocular involvement in PCNSL can impact patient prognosis and visual function.
- Understanding the characteristics of PCNSL with ocular involvement is crucial for timely diagnosis and management.
Purpose of the Study:
- To delineate the demographic and clinical features of patients with PCNSL and ocular involvement.
- To evaluate treatment strategies and outcomes for ocular PCNSL.
- To assess the impact of intraocular lymphoma on visual prognosis.
Main Methods:
- Retrospective chart review of 61 PCNSL patients diagnosed between January 2000 and October 2008.
- Ophthalmologic examinations were performed on 46 patients.
- Data analysis included demographics, clinical presentation, diagnostic methods, ocular findings, treatment, and survival duration.
Main Results:
- 13 out of 46 (28%) patients with PCNSL had intraocular involvement.
- The mean age at diagnosis was 52.8 years, with 54% being female.
- Ocular symptoms preceded CNS symptoms in 31% of cases, with decreased visual acuity being the most common symptom.
- Intraocular findings included vitritis/vitreous opacity and retinal infiltrative lesions.
- Treatment involved systemic chemotherapy/radiotherapy, with some patients receiving vitrectomy and/or intravitreal methotrexate.
- Mean survival duration was 32.2 months.
Conclusions:
- Ocular involvement is a significant feature in a notable proportion of PCNSL patients.
- Early recognition of ocular symptoms and prompt ophthalmologic evaluation are essential for diagnosing intraocular lymphoma.
- Dedicated treatment for intraocular lymphoma, alongside systemic therapy, may lead to better visual outcomes and potentially influence overall survival.
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