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Isotretinoin effect on alveolar repair after exodontia--a study in rats
Roberta Dalmolin Bergoli1, Otacilio Luiz Chagas Junior, Carlos Eduardo Chrzanowski Pereira de Souza
1Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, School of Dentistry, Universidade Federal de Pelotas, Rua Gonçalves Chaves, 3.657/401 B, Pelotas, Rio Grande do Sul, Brazil. betabergoli@hotmail.com
Objectives:
To evaluate isotretinoin effect on alveolar repair after tooth extraction of maxillary incisor and serum calcium levels in rats.
Study Design:
Wistar rats (60-day-old) were assigned to control (CG, n = 12) and experimental (EG, n = 20) groups. EG received daily isotretinoin (7.5 mg/kg) for 30 days before surgery and until euthanasia, 7, 21, 28, or 90 days after tooth extraction. Blood was collected in the EG to analyze serum calcium levels before isotretinoin administration and at euthanasia. Right hemimaxillae underwent histological examination, and the slides were stained with HE and analyzed by descriptive light microscopy.
Results:
There was acceleration in the process of alveolar repair in the EG at all time points when compared to controls. Serum calcium levels showed a statistically significant decrease between first and second blood collection at days 21, 28, and 90.
Conclusions:
Daily isotretinoin in a dose corresponding to the treatment of cystic acne accelerated alveolar repair.
