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Severe polyuria and polydipsia in hyponatremic-hypertensive syndrome associated with Wilms tumor

Paolo D'Angelo1, Serena Catania, Giusy Zirilli

  • 1Unit of Pediatric Hematology and Oncology, G. Di Cristina Children's Hospital, A.R.N.A.S., Palermo, Italy. oncoematoped@ospedalecivicopa.org

Pediatric Blood & Cancer
|July 27, 2010
PubMed

Insights

Hyponatremic-hypertensive syndrome (HHS) in children, rare and linked to renal artery issues, was successfully treated. Surgical removal of Wilms tumor resolved HHS symptoms, enabling further cancer treatment.

Area of Science:

  • Pediatric Nephrology
  • Pediatric Oncology
  • Hypertension Research

Background:

  • Hyponatremic-hypertensive syndrome (HHS) is a rare condition in children, often linked to renal artery occlusions.
  • It presents with low sodium levels and high blood pressure, requiring careful management.

Observation:

  • Two pediatric cases of HHS were observed with severe hypokalemia, polyuria, and polydipsia.
  • These symptoms were associated with the presence of Wilms tumor.

Findings:

  • Treatment with an angiotensin-converting enzyme inhibitor was initiated before surgical intervention.
  • Complete resolution of HHS signs and symptoms occurred only after the Wilms tumor was surgically resected.
  • Tumor resection facilitated the commencement of necessary chemotherapy.

Implications:

  • This case series highlights the critical link between Wilms tumor and HHS in pediatric patients.
  • Early diagnosis and surgical management of the tumor are crucial for resolving HHS.
  • Successful treatment of HHS enables effective oncological therapy, improving patient outcomes.

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