Related Experiment Video
Updated: Jun 10, 2026

High-resolution Tandem Mass Spectrometry for Studying Chemical Constituents of Gynura bicolor DC
Published on: February 2, 2024
A novel dimeric coumarin analog and antimycobacterial constituents from Fatoua pilosa
Chun-Ching Chiang1, Ming-Jen Cheng, Chien-Fang Peng
1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, R.O.C.
Abstract:
One novel dimeric coumarin analog, fatouapilosin (1), together with 18 known compounds, have been isolated from the whole plants of Fatoua pilosa. The structures of these isolates were elucidated by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, NOESY, HSQC, HMBC, and MS analyses). Among the tested compounds 2-14, scopoletin (3), isobavachalcone (12), and (E)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(2,2-dimethyl-8-hydroxy-2H-benzopyran-6-yl)prop-2-en-1-one (14) exhibited the strongest antimycobacterial activities against Mycobacterium tuberculosis H(37)Rv, with MIC values of 42, 18, and 30 microg/ml, respectively.
Related Concept Videos
Antifungal Agents
Anthelminthic Agents
Antiprotozoal Agents
Drugs that Stabilize Microtubules