Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Explicit Memories01:27

Explicit Memories

Explicit memories, also known as declarative memories, are consciously remembered, recalled, and reported. Studying for a chemistry exam involves material that will become part of explicit memory. There are two types of explicit memory: episodic and semantic.
Episodic memory contains information about personally experienced events and is reported as a story. An example of episodic memory is recalling a birthday celebration. This type of memory includes the what, where, and when of an event, as...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a virtual Ayurvedic whole-systems lifestyle intervention for quality of life in breast cancer survivors: An exploratory randomized controlled trial.

Explore (New York, N.Y.)·2026
Same author

Rethinking traffic safety: the case for reducing kinetic energy exposure, not just speed.

Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention·2026
Same author

Resolving METTL5 Specificity: Direct RNA Sequencing Reveals No Compelling Evidence for METTL5 mediated mRNA m6A Methylation in mESCs.

microPublication biology·2026
Same author

Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy.

bioRxiv : the preprint server for biology·2026
Same author

Multiomic analysis of ART-interruption cohorts identifies cell-extrinsic and -intrinsic mechanisms driving lymphocyte-mediated control of HIV rebound.

Immunity·2026
Same author

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations.

Molecular cell·2025

Related Experiment Video

Updated: Jun 10, 2026

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
12:08

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

What an epigenome remembers.

Ulrike C Lange1, Robert Schneider

  • 1Max Planck Institute for Immunobiology, Stübeweg 51, 79108 Freiburg, Germany.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|July 27, 2010
PubMed
Summary

Mammalian development requires faithful replication of DNA and epigenetic states. Some epigenetic marks escape germline reprogramming, enabling transgenerational epigenetic inheritance and transmission to offspring.

Area of Science:

  • Developmental Biology
  • Epigenetics
  • Genetics

Background:

  • Cell fate maintenance during mammalian development relies on accurate DNA and epigenetic state replication.
  • Germline cells possess mechanisms to erase epigenetic memory during development, resetting the epigenome.
  • Specific epigenetic marks can evade this reprogramming, potentially leading to transgenerational inheritance.

Purpose of the Study:

  • To discuss the molecular requirements for the faithful transmission of epigenetic information.
  • To review current knowledge on how epigenetic information is transmitted across generations.

Main Methods:

  • Literature review and synthesis of existing research on epigenetic inheritance.
  • Analysis of molecular mechanisms governing epigenetic state maintenance and reprogramming.

More Related Videos

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

Related Experiment Videos

Last Updated: Jun 10, 2026

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
12:08

Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells

Published on: March 10, 2016

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue
09:43

Purification of H3 and H4 Histone Proteins and the Quantification of Acetylated Histone Marks in Cells and Brain Tissue

Published on: November 30, 2018

Main Results:

  • Identified key molecular factors and processes involved in epigenetic information transmission.
  • Highlighted specific epigenetic marks that resist germline reprogramming.
  • Provided an overview of the current understanding of transgenerational epigenetic inheritance.

Conclusions:

  • Faithful epigenetic information transmission is crucial for development and inheritance.
  • Understanding the molecular basis of epigenetic memory escape is key to deciphering transgenerational inheritance patterns.