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Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Globular Proteins01:27

Globular Proteins

In organisms, proteins are the most abundant macromolecules. They act as the building blocks of life and play various crucial roles in the body. Proteins can be broadly classified into two distinct subtypes based on their shape and solubilities: globular proteins and fibrous proteins.
Globular proteins serve many important physiological functions, such as acting as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be soluble in the aqueous...

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Detecting and Characterizing Protein Self-Assembly In Vivo by Flow Cytometry
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Detecting and Characterizing Protein Self-Assembly In Vivo by Flow Cytometry

Published on: July 17, 2019

Homomeric protein complexes: evolution and assembly.

A J Venkatakrishnan1, Emmanuel D Levy, Sarah A Teichmann

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.

Biochemical Society Transactions
|July 28, 2010
PubMed
Summary
This summary is machine-generated.

Homo-oligomeric protein complexes are essential in cells. This review covers their structure, symmetry, evolution, and assembly, providing insights into these vital biological assemblies.

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Area of Science:

  • Biochemistry
  • Structural Biology
  • Evolutionary Biology

Background:

  • Homo-oligomeric protein complexes are crucial for cellular functions.
  • These complexes are abundant and diverse in living organisms.
  • Understanding their structure and assembly is key to comprehending cellular processes.

Purpose of the Study:

  • To review the current knowledge on the geometry and evolution of homo-oligomeric protein complexes.
  • To discuss the symmetry principles governing these protein assemblies.
  • To explore the interfaces involved in protein-protein interactions within these complexes.

Main Methods:

  • Review of existing literature on protein complex structure and evolution.
  • Analysis of symmetry in protein complex architecture.
  • Discussion of experimental and computational approaches to study assembly pathways.

Main Results:

  • Homo-oligomeric complexes exhibit diverse geometric arrangements and evolutionary histories.
  • Symmetry plays a critical role in the stability and function of these complexes.
  • Specific interaction interfaces dictate complex formation and specificity.

Conclusions:

  • The geometry, symmetry, and evolution of homo-oligomeric complexes are interconnected.
  • Understanding assembly pathways provides insights into biological regulation.
  • Further research can elucidate the functional significance of complex architecture.