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Comparison of risk of neurovascular and cardiovascular side effects between tiotropium and other anticholinergic

Reem Alzayer1, Jeffery Hughes, Richard Parsons

  • 1Curtin University of Technology, Perth, Australia.

Quality in Primary Care
|July 28, 2010
PubMed
Abstract

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Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations,  while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and the conjunctiva.
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Cholinergic Antagonists: Therapeutic Uses

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Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal secretions in common...
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Cholinergic Antagonists: Pharmacological Actions

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