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[Effect of captopril on pulmonary function]
A S Ayache1, V Salman, Y M Traub
1Dept. of Internal Medicine A, Rebecca Sieff Government Hospital, Safed.
Harefuah
|February 15, 1991
Summary
Angiotensin converting enzyme (ACE) inhibitors can cause dry cough. A single captopril dose did not alter bronchial tone in any group, suggesting ACE inhibitor cough is not asthma-related.
Area of Science:
- Pharmacology
- Pulmonology
- Clinical Medicine
Context:
- Dry cough is a known side effect of angiotensin converting enzyme (ACE) inhibitors.
- Previous research has explored the long-term effects of ACE inhibitors on lung function.
- The exact mechanism behind ACE inhibitor-induced cough remains unclear.
Purpose:
- To investigate the immediate effect of a single oral dose of captopril on bronchial tone.
- To assess if bronchial tone changes are linked to ACE inhibitor-induced cough.
- To explore the potential asthmatic basis of cough associated with ACE inhibitors.
Summary:
- A single 25 mg oral dose of captopril was administered to healthy controls, patients with obstructive pulmonary disease, and patients who previously experienced cough with ACE inhibitors.
- Spirometric tests were conducted one hour post-ingestion.
- No significant changes in spirometric parameters were observed in any participant group.
Impact:
- Findings suggest that the cough associated with ACE inhibitors does not appear to stem from an asthmatic mechanism.
- This study contributes to understanding the non-asthmatic pathogenesis of ACE inhibitor-induced cough.
- Results complement existing data on the pulmonary effects of ACE inhibitors.