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Related Experiment Video

Updated: Jun 10, 2026

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
06:33

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement

Published on: July 29, 2013

Tumor pH and its measurement.

Xiaomeng Zhang1, Yuxiang Lin, Robert J Gillies

  • 1Biomedical Engineering Program, University of Arizona, Tucson, Arizona, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|July 28, 2010
PubMed
Summary

Solid tumors maintain a neutral intracellular pH but an acidic extracellular pH, potentially driving aggressive cancer. Recent advances in imaging techniques now allow for more accurate in vivo tumor pH measurements.

Area of Science:

  • Oncology
  • Medical Imaging
  • Biochemistry

Background:

  • Solid tumors exhibit distinct intracellular (7.0-7.2) and acidic extracellular pH.
  • Acidic tumor extracellular pH is linked to more aggressive cancer phenotypes.
  • Accurate tumor pH measurement is crucial for understanding cancer progression.

Purpose of the Study:

  • To review recent advancements in in vivo tumor pH measurement techniques.
  • To highlight the role of pH-sensitive imaging in cancer research.

Main Methods:

  • Positron Emission Tomography (PET) with pH-sensitive radiotracers.
  • Magnetic Resonance (MR) spectroscopy and imaging (MRI).
  • Optical imaging techniques.

Main Results:

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Last Updated: Jun 10, 2026

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Published on: July 29, 2013

In Vivo EPR Assessment of pH, pO2, Redox Status, and Concentrations of Phosphate and Glutathione in the Tumor Microenvironment
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  • Significant progress has been made in developing and applying advanced imaging modalities for in vivo tumor pH assessment.
  • These techniques offer improved accuracy, precision, and reproducibility in pH measurements.
  • Recent methods enable detailed investigation of tumor microenvironment pH.

Conclusions:

  • In vivo tumor pH measurement has advanced significantly over the past decade.
  • pH-sensitive PET, MR spectroscopy, MRI, and optical imaging are key tools for studying tumor acidity.
  • These imaging advances are vital for understanding the role of pH in cancer aggressiveness.