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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
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Proinflammatory T helper type 17 cells are effective B-cell helpers

Meike Mitsdoerffer1, Youjin Lee, Anneli Jäger

  • 1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Proceedings of the National Academy of Sciences of the United States of America
|July 28, 2010
PubMed
Summary

T helper type 17 (TH17) cells, known for inflammation, also act as B-cell helpers. They promote B-cell proliferation, antibody production, and class switch recombination, particularly IgG2a and IgG3 subtypes.

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