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Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...

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Related Experiment Video

Updated: Jun 10, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Stillbirth: fetal disorders.

Richard M Pauli1

  • 1Department of Pediatrics, University of Wisconsin, Madison, Wisconsin 53705, USA. pauli@waisman.wisc.edu

Clinical Obstetrics and Gynecology
|July 28, 2010
PubMed
Summary
This summary is machine-generated.

Fetal disorders are a common cause of stillbirth, yet thorough evaluations are underused. Identifying a fetal cause impacts family counseling and care, highlighting the need for better stillbirth assessment and research.

Related Experiment Videos

Last Updated: Jun 10, 2026

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis
06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

Area of Science:

  • Perinatal Medicine
  • Fetal Pathology
  • Reproductive Health

Background:

  • Fetal disorders and congenital malformations are leading causes of intrauterine death.
  • Comprehensive fetal assessment methods, including history, examination, imaging, and necropsy, are available but underutilized.
  • Current practices result in a significant proportion of stillborn infants lacking a determined cause of death.

Purpose of the Study:

  • To emphasize the importance and underutilization of fetal disorder assessment in stillbirth.
  • To highlight the diagnostic yield and implications of identifying fetal causes of death.
  • To identify unmet needs in research and clinical practice for stillbirth evaluation.

Main Methods:

  • Review of standard diagnostic procedures for fetal death assessment.
  • Analysis of the frequency and heterogeneity of fetal causes of death.
  • Evaluation of the impact of fetal diagnosis on family counseling and care.

Main Results:

  • Approximately one-fifth of stillborn infants have an identifiable fetal cause of death when appropriately assessed.
  • Fetal diagnoses are diverse, with no single cause dominating.
  • Identifying a fetal cause influences counseling and care in over half of evaluated cases.

Conclusions:

  • Underutilization of thorough fetal assessment contributes to unexplained stillbirths.
  • Identifying fetal causes of death is crucial for informed family support and future reproductive planning.
  • There is a critical need for increased funding, research into intrauterine effects, and development of multidisciplinary stillbirth evaluation expertise.