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Updated: Jun 10, 2026

Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands

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The Sno oncogene antagonizes Wingless signaling during wing development in Drosophila

Janine C Quijano1, Michael J Stinchfield, Brad Zerlanko

  • 1School of Life Sciences, Arizona State University, Tempe, Arizona, United States of America.

Plos One
|July 28, 2010
PubMed

Insights

The Sno protein antagonizes Wingless (Wg) signaling during fruit fly development. This study clarifies Sno

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The Sno oncogene (Snoo/dSno) is a conserved protein known to antagonize Transforming Growth Factor-beta signaling.
  • Previous studies on Sno mutants in flies and mice have yielded enigmatic results regarding its developmental roles.
  • Conflicting data on the lethality of dSno mutations necessitated reconciliation to understand its function.

Purpose of the Study:

  • To identify developmental roles of dSno by analyzing its function in fruit fly wing development.
  • To investigate the interaction between dSno and the Wingless (Wg) signaling pathway.

Main Methods:

  • Analysis of dSno loss-of-function genotypes in Drosophila melanogaster wing development.
  • Conducting gain-of-function analyses to observe reciprocal phenotypes.
  • Reconciliation of conflicting data regarding dSno mutation lethality.

Main Results:

  • Loss of dSno function resulted in ectopic margin bristles and campaniform sensilla in the anterior wing compartment.
  • Gain of dSno function led to the opposite phenotype: loss of bristles and sensilla.
  • These findings suggest dSno antagonizes Wingless (Wg) signaling in target cells.

Conclusions:

  • dSno functions as a tissue-specific antagonist of the Wingless (Wg) signaling pathway during Drosophila development.
  • dSno exhibits modest antagonistic activity under normal conditions but can block excessive Wg signaling.
  • This antagonistic role of dSno in Wg signaling may be conserved in vertebrates.

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