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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffusion tensor imaging and decision making in cocaine dependence.

Scott D Lane1, Joel L Steinberg, Liangsuo Ma

  • 1Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States of America. scott.d.lane@uth.tmc.edu

Plos One
|July 28, 2010
PubMed
Summary
This summary is machine-generated.

Chronic cocaine abuse impairs decision-making abilities and white matter integrity. This study links reduced white matter integrity in cocaine-dependent individuals to poorer performance on the Iowa Gambling Task (IGT).

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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
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Published on: November 8, 2012

Area of Science:

  • Neuroscience
  • Addiction Research
  • Cognitive Psychology

Background:

  • Chronic stimulant abuse, particularly cocaine, is linked to decision-making deficits.
  • Structural brain abnormalities, including in white matter, are observed in stimulant abusers.
  • These structural changes may underlie functional behavioral impairments.

Purpose of the Study:

  • To investigate the relationship between white matter integrity and decision-making in cocaine dependence.
  • To compare white matter integrity and gambling task performance between cocaine-dependent individuals and controls.

Main Methods:

  • Diffusion Tensor Imaging (DTI) was used to assess white matter integrity.
  • Fractional anisotropy (FA) and lambda perpendicular were measured.
  • Performance on the Iowa Gambling Task (IGT) was evaluated.

Main Results:

  • Cocaine-dependent subjects exhibited lower FA and higher lambda perpendicular in frontal, parietal, and corpus callosum white matter compared to controls.
  • Cocaine users demonstrated significantly worse performance on the IGT, especially in later trials.
  • White matter integrity measures (FA and lambda perpendicular) correlated with IGT performance.

Conclusions:

  • Compromised white matter integrity is associated with impaired decision-making in cocaine dependence.
  • DTI findings suggest structural brain changes contribute to cognitive deficits in addiction.