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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization
Lahssen El Blidi1, Nicolas Vanthuyne, Didier Siri
1Equipe Chimie Moléculaire Organique, LCP UMR 6264, Boite 562, Université Paul Cézanne, Faculté des Sciences St Jérôme, Avenue Escadrille Normandie-Niemen, 13397, Marseille Cedex 20, France.
Abstract:
Chemoenzymatic dynamic kinetic resolution (DKR) of amines involving sulfanyl radical-induced racemization happened to be the very first switchable DKR process allowing the synthesis of either (R)- or (S)-amides, in good yield and high enantiomeric excess, depending on the nature of the enzyme; the different steps of the development of (S)-selective DKR are discussed.
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