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Updated: Jun 10, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Impact of Integrated Model for Rational Use of Antibiotics in a health area (project MIURA)]

Javier Colomina Rodríguez1, Victoria Domínguez Márquez, Flor Gimeno Vilarrasa

  • 1Servicio de Microbiología, Hospital Universitario de La Ribera, Alzira, Valencia, España. jcolomina@hospital-ribera.com

Revista Espanola De Salud Publica
|July 28, 2010
PubMed
Abstract

Insights

The MIURA project successfully reduced antibiotic consumption by 15% through targeted interventions. However, antibiotic dispensing increased again after the project concluded, highlighting the need for sustained antimicrobial stewardship.

Area of Science:

  • Public Health
  • Infectious Disease Management
  • Pharmacoeconomics

Background:

  • The MIURA (Integrated Model for the Rational Use of Antimicrobials) project aimed to optimize antibiotic prescribing.
  • It ran from January 2004 to December 2006, involving healthcare professionals and patients.

Purpose of the Study:

  • To analyze trends in antibiotic consumption.
  • To evaluate the impact of the MIURA project on antibiotic use in a specific health area.

Main Methods:

  • A comparative study analyzed antibiotic dispensing data from 2000-2008.
  • Data was collected via the GAIA application in Valencia's Health Department 11.
  • Antibiotic consumption was measured in DHD (defined daily doses per 1,000 inhabitants per day).

Main Results:

  • Antibiotic consumption decreased by 15% (4.02 DHD) during the MIURA project (2004-2006).
  • Statistically significant reductions were observed for macrolides and cephalosporins.
  • Post-project (2007-2008), antibiotic dispensing showed an increasing trend.

Conclusions:

  • The MIURA program effectively reduced antibiotic prescriptions during its implementation.
  • Sustained efforts are needed to maintain reduced antibiotic consumption beyond the project's duration.

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