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Pemphigus in children.

A J Kanwar1, S Kaur

  • 1Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

International Journal of Dermatology
|May 1, 1991
PubMed
Summary
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This study reports on seven boys with pemphigus, a rare autoimmune blistering disease. All patients experienced an excellent prognosis following treatment with corticosteroids.

Area of Science:

  • Dermatology
  • Autoimmune Diseases
  • Pediatrics

Background:

  • Pemphigus is a group of rare autoimmune blistering diseases.
  • Pemphigus vulgaris and pemphigus foliaceus are the most common subtypes.
  • Pediatric autoimmune blistering diseases are uncommon, with limited case reports.

Observation:

  • This report details seven male pediatric patients diagnosed with pemphigus.
  • The youngest patient presented with disease onset at age seven.
  • Six boys had pemphigus vulgaris, and one boy had pemphigus foliaceus.

Findings:

  • Three patients with pemphigus vulgaris received intravenous dexamethasone pulse therapy.
  • The remaining four patients were treated with oral corticosteroid therapy.

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  • All seven pediatric patients achieved an excellent prognosis, indicating successful disease management.

    • Implications:

    • Corticosteroid therapy, both intravenous and oral, appears effective in managing pediatric pemphigus.
    • Early diagnosis and prompt treatment are crucial for favorable outcomes in pediatric autoimmune blistering diseases.
    • Further research into long-term outcomes and potential side effects of corticosteroid treatment in children is warranted.