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Updated: Jun 10, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
[Recent advances in the research on HDL subfraction]
Takashi Miida1, Satoshi Hirayama
1Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan. tmiida@juntendo.ac.jp
Rinsho Byori. the Japanese Journal of Clinical Pathology
|July 29, 2010
Summary
High-density lipoprotein (HDL) is vital for cholesterol transport and predicting heart disease. Measuring HDL subfractions offers a more precise way to assess coronary heart disease risk.
Area of Science:
- Lipidology and cardiovascular research.
- Biochemistry of lipoproteins and cholesterol metabolism.
Context:
- High-density lipoprotein (HDL) is crucial for reverse cholesterol transport.
- HDL-cholesterol (HDL-C) levels are inversely correlated with coronary heart disease (CHD) incidence.
- HDL particles are heterogeneous, with varying compositions and functions.
Purpose:
- To review methods for measuring HDL subfractions.
- To discuss the clinical significance of HDL subfractions.
- To explore future perspectives in HDL subfraction analysis.
Summary:
- HDL, the smallest lipoprotein, is key in reverse cholesterol transport.
- Measuring HDL subfractions provides more precise coronary heart disease (CHD) risk prediction than total HDL-C.
- This review covers current measurement techniques, clinical relevance, and future directions in HDL subfraction analysis.
Impact:
- Enhanced understanding of HDL's role in cardiovascular health.
- Improved diagnostic and prognostic tools for coronary heart disease.
- Informing the development of targeted HDL-based therapies.
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