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Disorders of Hemostasis

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Related Experiment Video

Updated: Jun 10, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

[Colorectal malignancies with respect to hemocoagulation].

M Mýtnik¹, P Kubisz, J Stasko

¹Chirurgická klinika FNsP Presov, Slovenská republika. mytnik@fnsppresov.sk

Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti

|July 29, 2010

Summary

This summary is machine-generated.

Preoperative thrombotic markers like D-dimer and PAI-1 indicate thrombosis risk and disease stage in colorectal cancer patients, guiding surgical approach.

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Last Updated: Jun 10, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

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Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

Area of Science:

Oncology
Hematology
Clinical Pathology

Context:

Malignant tumors, particularly colorectal cancer, are known to affect the body's blood clotting system (hemocoagulation).
Understanding these changes is crucial for patient management and predicting outcomes.

Purpose:

To analyze hemocoagulation damage in colorectal cancer patients.
To evaluate specific thrombotic markers, including D-dimer, Plasminogen Activator Inhibitor-1 (PAI-1), Prothrombin Fragment 1+2 (F 1+2), and Protein C levels.
To correlate these markers with tumor aggressiveness and clinical stage.

Summary:

Analysis of 137 colorectal cancer patients revealed that aggressive tumors correlate with elevated D-dimer and PAI-1 levels.
Increased Prothrombin Fragment 1+2 was observed in cases of anastomotic dehiscence.
Reduced Protein C levels were noted in older patients (6th-7th decades) and those with advanced disease stages.

Impact:

Preoperative assessment of thrombotic markers can inform about the risk of thrombosis and the patient's clinical disease stage.
These markers, especially D-dimer and PAI-1, offer significant validity in risk assessment.
Findings may influence the preference for minimally invasive surgical procedures.