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Related Experiment Video

Updated: Jun 10, 2026

Orthotopic Small Bowel Transplantation in Rats
09:16

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

[Experimental small intestine transplantation].

M Oliverius1, M Kudla, P Baláz

  • 1Klinika transplantacní chirurgie IKEM, Praha.

Rozhledy V Chirurgii : Mesicnik Ceskoslovenske Chirurgicke Spolecnosti
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

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This study refined small intestine transplantation techniques in pigs, finding central vascular connections reduced surgical complications. Tacrolimus monotherapy and combination therapy showed similar efficacy in preventing rejection, with histology as the gold standard for diagnosis.

Area of Science:

  • Surgical innovation in transplantation medicine.
  • Gastroenterology and hepatology research.
  • Immunology and rejection mechanisms.

Context:

  • Small intestinal failure necessitates transplantation.
  • Optimizing surgical techniques and immunosuppression is crucial for graft survival.
  • Accurate diagnosis of graft rejection is vital for patient management.

Purpose:

  • To master small intestine graft collection and transplantation techniques.
  • To optimize immunosuppression regimens for allogeneic grafts.
  • To diagnose acute cellular graft rejection using cellular and humoral indicators.

Summary:

  • 43 pig small intestine transplantations were performed, evaluating two vascular anastomosis methods and four immunosuppression strategies.

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A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

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Related Experiment Videos

Last Updated: Jun 10, 2026

Orthotopic Small Bowel Transplantation in Rats
09:16

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

Small Bowel Transplantation In Mice
36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
08:25

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

Published on: June 10, 2025

  • Central vascular connections (aorta/vena cava) resulted in fewer surgical complications compared to mesenteric vessel connections.
  • Histological examination confirmed its status as the gold standard for diagnosing cellular rejection, while plasma citrulline showed no diagnostic significance.

    • Impact:

    • Successfully refined surgical techniques for small intestine transplantation.
    • Demonstrated the efficacy of tacrolimus-based immunosuppression, with no significant difference between monotherapy and combination therapy with sirolimus.
    • Established histological examination as the definitive method for diagnosing cellular rejection in small intestine allografts.