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Updated: Jun 10, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Lifestyle interventions, insulin resistance, and renal artery stiffness in essential hypertension
Guglielmo M Trovato1, Clara Pirri, Giuseppe Fabio Martines
1Dipartimento di Medicina Interna, Istituto di Medicina Interna e Terapia Medica Facoltà di Medicina e Chirurgia, Università di Catania, Italy. guglielmotrovato@unict.it
Abstract:
The study investigates lifestyle and effective anti-hypertensive intervention in overweight-obese patients can influence insulin-resistance (HOMA-IR) and US Renal-Resistive-Index (RRI). After a 1-year interventional program (including a personalized Mediterranean diet, physical activity increase, smoking withdrawal counseling), 156 Essential Hypertension (EH) patients still have abnormal HOMA-IR, significantly higher in comparison to 159 control group patients. Body mass index (BMI) and cholesterol-high-density-lipoprotein improvement are the best predictors of a HOMA-IR decrease; RRI improves in EH according to lifestyle interventions, but no predictor to RRI is identified. Persistence of IR can be tentatively assumed as a steady sign, persistent also after extended lifestyle intervention in EH, further warranting more intensive dietary interventions.
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