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Screening for coagulation disorders in patients with ischemic stroke

Lonneke Ml de Lau1, Frank Wg Leebeek, Moniek Pm de Maat

  • 1Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. l.delau@erasmusmc.nl

Expert Review of Neurotherapeutics
|July 29, 2010
PubMed

Insights

Coagulation disorders

Area of Science:

  • Neurology
  • Hematology
  • Genetics

Background:

  • The link between coagulation disorders and ischemic stroke is not fully understood.
  • Screening for these conditions and managing them post-stroke remains uncertain.

Purpose of the Study:

  • To review data on coagulation abnormalities and ischemic stroke.
  • To discuss the utility of screening and management strategies.

Main Methods:

  • Literature review of inherited and acquired coagulation disorders.
  • Analysis of their association with ischemic stroke.
  • Evaluation of screening and management recommendations.

Main Results:

  • Evidence on the role of specific coagulation abnormalities (e.g., Factor V Leiden, antiphospholipid syndrome) in ischemic stroke was reviewed.
  • The clinical utility of screening and therapeutic implications were assessed.

Conclusions:

  • The role of coagulation disorders in ischemic stroke pathogenesis requires further elucidation.
  • Evidence-based recommendations for screening and management are discussed.

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