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Related Experiment Video

Updated: Jun 10, 2026

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice
17:45

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Published on: February 26, 2012

Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function.

N Sagata1, A Iwaki, T Aramaki

  • 1Division of Human Molecular Genetics, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Higashi-ku, Fukuoka, Japan.

Genes, Brain, and Behavior
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

Mice lacking the GluR4 subunit showed altered spatial memory and impaired prepulse inhibition, suggesting this AMPA receptor subunit influences cognitive functions and may be linked to neurological disorders.

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Last Updated: Jun 10, 2026

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Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • AMPA-type glutamate receptors mediate fast excitatory neurotransmission in the mammalian brain.
  • The GluR4 subunit is crucial for synaptic plasticity and neural circuit development, particularly in the cerebellum and hippocampus.
  • Previous studies linked the human GRIA4 gene (encoding GluR4) to schizophrenia.

Purpose of the Study:

  • To investigate the role of the GluR4 subunit in higher brain functions.
  • To analyze the impact of GluR4 gene deletion on electrophysiological and behavioral outcomes.

Main Methods:

  • Generation of GluR4 knockout mice.
  • Electrophysiological recordings, including long-term potentiation (LTP) in the hippocampus.
  • Behavioral tests: T-maze, Barnes circular maze, and prepulse inhibition assay.

Main Results:

  • GluR4 knockout mice exhibited normal hippocampal LTP.
  • Mildly improved spatial working memory in the T-maze test.
  • Impaired acquisition of spatial reference memory in the Barnes circular maze test.
  • Deficits in prepulse inhibition were observed.

Conclusions:

  • The GluR4 subunit plays a significant role in cognitive functions, including spatial memory and sensory gating.
  • These findings support the involvement of GluR4 in neurological and psychiatric conditions.