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Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

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Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
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Published on: April 15, 2021

Gene transfer for experimental saccular aneurysms.

T Okamoto1, S Miyachi, M Negoro

  • 1Department of Neurosurgery, Toyohashi Municipal Hospital; Nagoya, Japan.

Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

Gene therapy shows promise for reinforcing aneurysm walls to prevent rupture. Researchers successfully used adenovirus to deliver genes into experimental aneurysms, observing positive wall remodeling without adverse effects.

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Area of Science:

  • Vascular Biology
  • Gene Therapy
  • Regenerative Medicine

Background:

  • Aneurysm rupture is a life-threatening event.
  • Reinforcing the aneurysmal wall is a potential preventative strategy.
  • Gene transfer offers a novel approach for tissue remodeling.

Purpose of the Study:

  • To investigate the feasibility of focal gene transfer for remodeling experimental aneurysms.
  • To assess the safety and efficacy of adenovirus-mediated gene delivery to the aneurysmal wall.

Main Methods:

  • Created experimental saccular aneurysms in canine carotid arteries using an artificial dissecting method.
  • Administered adenovirus vector (AxCALacZ, 10(8) pfu) via slow injection into the aneurysm cavity.
  • Utilized balloon-assisted neck-plasty for intraaneurysmal flow arrest during gene delivery.
  • Evaluated transgene expression (beta-galactosidase) using X-gal staining 48 hours post-transduction.

Main Results:

  • Beta-galactosidase expression was primarily detected in the intima of the treated aneurysms.
  • No adverse effects were observed on the normal carotid artery wall.
  • No systemic complications were noted following the gene transfer procedure.

Conclusions:

  • Focal gene transfer is a potential strategy for reinforcing aneurysmal walls.
  • Adenovirus-mediated gene delivery demonstrated localized expression and safety in experimental aneurysms.
  • This study suggests the potential of gene therapy for treating cerebral aneurysms.