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Novel use of insulin in continuous-instillation negative pressure wound therapy as "wound chemotherapy"

Christy L Scimeca1, Manish Bharara, Timothy K Fisher

  • 1Southern Arizona Limb Salvage Alliance (SALSA), College of Medicine, University of Arizona, Tucson, Arizona 85724, USA.

Journal of Diabetes Science and Technology
|July 29, 2010
PubMed

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...