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Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

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Toward an injectable continuous osmotic glucose sensor.

Erik Johannessen¹, Olga Krushinitskaya, Andrey Sokolov

¹Vestfold University College, Tønsberg, Norway. eaj@hive.no

Journal of Diabetes Science and Technology

|July 29, 2010

Summary

A new osmotic pressure sensor prototype offers long-term, in vivo blood glucose (BG) tracking for diabetes management. This injectable device enables tight glycemic control, potentially improving patient health outcomes.

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Published on: January 4, 2018

Area of Science:

Biomedical Engineering
Sensor Technology
Diabetes Research

Background:

Diabetes mellitus presents a significant societal and economic burden.
Effective glycemic control is crucial for mitigating diabetes complications.
Advanced tools for long-term in vivo blood glucose monitoring are needed.

Purpose of the Study:

To develop and evaluate a novel osmotic pressure-based sensor for continuous blood glucose monitoring.
To demonstrate the feasibility of an injectable device for diabetes management.

Main Methods:

Utilized a reversible competitive affinity assay for glucose-specific recognition.
Integrated a pressure transducer with silicon micro/nanofabrication components.
Developed a pill-shaped implant with a nanoporous membrane.

Main Results:

The in vitro model demonstrated a dynamic glucose detection range of 36-720 mg/dl with +/-16 mg/dl resolution.
The sensor system operated at a low power consumption of 76 microW.
The prototype successfully performed in vitro for up to four weeks.

Conclusions:

A prototype osmotic sensor using an affinity assay was designed, laid out, and tested in vitro.
The sensor's small size is suitable for an injectable device.
This technology forms the basis for a conceptual monitor for tight glycemic control.