Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MMP9 Genotype and Systemic T-Cell Subsets Correlate With Structural and Functional Outcomes in Neovascular Age-Related Macular Degeneration.

Investigative ophthalmology & visual science·2026

Same author

Surgical Management and Outcomes of Large High Myopic Macular Holes: Global Macular Hole Multicenter Study 3.

Retina (Philadelphia, Pa.)·2026

Same author

A Single-Center Analysis of Variables Used to Select a Vitreoretinal Surgery Training Program.

Journal of vitreoretinal diseases·2026

Same author

Rectus Muscle Metastasis from Primary Uveal Melanoma: A Case Series and Literature Review.

Ocular oncology and pathology·2026

Same author

Belzutifan for Ocular Tumors in Patients with von Hippel-Lindau Disease.

Ocular oncology and pathology·2025

Same author

Modeling MEK inhibitor-Associated Retinopathy <i>in vitro</i> using human induced pluripotent stem cell-derived retinal pigment epithelial cells.

bioRxiv : the preprint server for biology·2025

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Diffuse anterior retinoblastoma without retinal involvement.

Susannah Q Longmuir¹, Nasreen A Syed, H Culver Boldt

¹Department of Ophthalmology and Visual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.

|July 29, 2010

Summary

This summary is machine-generated.

A rare case of diffuse anterior retinoblastoma in a child presented as pseudouveitis. Early diagnosis and treatment, including enucleation and chemotherapy, led to a 5-year tumor-free survival.

More Related Videos

Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Related Experiment Videos

Last Updated: Jun 10, 2026

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Establishment and Propagation of Human Retinoblastoma Tumors in Immune Deficient Mice

Published on: August 4, 2011

Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Area of Science:

Ophthalmology
Pediatric Oncology
Pathology

Background:

Retinoblastoma typically originates in the retina.
Anterior segment involvement is rare, often mimicking other conditions like uveitis.

Observation:

An 8.5-year-old child presented with unilateral anterior pseudouveitis.
Initial treatment with corticosteroids showed no improvement.

Findings:

Fine-needle aspiration biopsy revealed a primitive neuroectodermal neoplasm, favoring retinoblastoma.
Histopathology confirmed diffuse infiltration of the anterior segment (iris, trabecular meshwork, sclera) without retinal involvement.
Immunohistochemistry supported the diagnosis of retinoblastoma.

Implications:

This case highlights diffuse anterior retinoblastoma as a distinct entity.
Aggressive multimodal treatment (enucleation, chemotherapy, radiation) can achieve long-term survival.
Emphasizes the importance of considering retinoblastoma in anterior segment tumors, even without retinal findings.