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Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...

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Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
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Telocytes in human term placenta: morphology and phenotype.

Laura Suciu1, Laurenţiu M Popescu, Mihaela Gherghiceanu

  • 1Department of Cellular and Molecular Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.

Cells, Tissues, Organs
|July 29, 2010
PubMed
Summary

Telocytes (TC), previously known as interstitial Cajal-like cells, are confirmed to be present in the human term placenta. This study details their unique ultrastructure, immunophenotype, and interactions with placental stromal cells.

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Area of Science:

  • Cell Biology
  • Histology
  • Reproductive Biology

Background:

  • Interstitial Cajal-like cells (ICLC) have been identified in various organs.
  • These cells are now termed telocytes (TC) and possess distinct long, thin processes called telopodes (TP).
  • Previous research has not extensively documented TC presence and characteristics in the human placenta.

Purpose of the Study:

  • To investigate the presence and characteristics of telocytes (TC) in the human term placenta.
  • To provide evidence on the ultrastructure, immunophenotype, distribution, and cell interactions of TC within the placental villous core.
  • To contribute to the understanding of TC in placental biology.

Main Methods:

  • Utilized phase-contrast microscopy, light microscopy, and transmission electron microscopy for ultrastructural analysis.
  • Employed immunohistochemistry and immunofluorescence on tissue sections and cell cultures for immunophenotyping.
  • Followed a pre-established diagnostic algorithm for cell identification.

Main Results:

  • Transmission electron microscopy revealed cells resembling TC, with approximately 76% exhibiting characteristic thin, long processes (telopodes).
  • TC in situ showed positive staining for c-kit, CD34, vimentin, caveolin-1, VEGF, and iNOS.
  • Cell cultures indicated co-expression of c-kit, vimentin, and caveolin-1 in ~13% of cells with a TC morphology.

Conclusions:

  • This study confirms the presence of telocytes (TC) in the human term placenta.
  • Provides a detailed ultrastructural and immunophenotypic characterization of placental TC.
  • Highlights potential roles of TC in placental stromal cell interactions.