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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...

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Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
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Confluent thalamic hyperintensities in CADASIL.

Mathilde Jacqmin1, Dominique Hervé, Anand Viswanathan

  • 1Service de Neurologie, Centre de référence pour les maladies rares des vaisseaux du cerveau et de l'oeil (CERVCO), INSERM U740, CHU Lariboisière, APHP, Paris, France.

Cerebrovascular Diseases (Basel, Switzerland)
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

Confluent thalamic hyperintensities (CTH) are common in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) patients. These MRI findings correlate with white matter lesion load but not cognitive decline.

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Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
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Published on: November 20, 2015

Area of Science:

  • Neuroimaging
  • Neurology
  • Vascular Dementia

Background:

  • Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is characterized by white matter hyperintensities and lacunar infarcts.
  • The prevalence and clinical significance of confluent thalamic hyperintensities (CTH) in CADASIL are not well understood.

Purpose of the Study:

  • To investigate the frequency and MRI characteristics of CTH in CADASIL patients.
  • To determine the association of CTH with clinical manifestations and other MRI markers in CADASIL.

Main Methods:

  • FLAIR and T1-weighted MRI sequences were used to assess thalamic hyperintensities in 147 CADASIL patients.
  • Diffusion-weighted imaging was analyzed for increased diffusion areas.
  • Generalized linear regression models were employed to analyze associations with clinical and imaging variables.

Main Results:

  • CTH were detected in 12% of CADASIL patients, appearing as hypointensities on T1-weighted images and areas of increased diffusion.
  • CTH were significantly associated with age and the volume of white matter hyperintensities.
  • No significant association was found between CTH and lacunar infarcts, cerebral atrophy, or cognitive performance.

Conclusions:

  • CTH are a notable finding on FLAIR MRI in a significant proportion of CADASIL patients.
  • CTH are primarily linked to the extent of white matter hyperintensities and do not correlate with cognitive decline.
  • Demyelination and/or glial cell loss are the likely underlying causes of CTH in CADASIL.