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Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...

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Related Experiment Video

Updated: Jun 10, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Chorioamnionitis and cerebral palsy: a meta-analysis.

Jobe G Shatrov1, Samuel C M Birch, Lawrence T Lam

  • 1From School of Medicine, Sydney, The University of Notre Dame Australia; and Cerebral Palsy Institute, Darlinghurst, New South Wales, Australia.

Obstetrics and Gynecology
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

Chorioamnionitis, an infection during pregnancy, is significantly linked to cerebral palsy (CP). Preventing this infection could reduce CP rates in newborns, highlighting the need for improved diagnostic methods.

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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
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Related Experiment Videos

Last Updated: Jun 10, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

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Published on: November 20, 2015

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

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Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
05:04

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

Published on: February 2, 2024

Area of Science:

  • Perinatal Medicine
  • Neurology
  • Infectious Diseases

Background:

  • Cerebral palsy (CP) is a significant cause of long-term disability in children.
  • Intrauterine infections, including chorioamnionitis, are suspected contributors to CP development.
  • Understanding the precise relationship between chorioamnionitis and CP is crucial for prevention strategies.

Purpose of the Study:

  • To conduct a meta-analysis examining the association between clinical or histological chorioamnionitis and cerebral palsy.
  • To quantify the risk of cerebral palsy associated with chorioamnionitis.

Main Methods:

  • Systematic review of PubMed-indexed literature from 2000-2009.
  • Inclusion of studies reporting on chorioamnionitis (clinical or histological) and cerebral palsy diagnoses.
  • Meta-analysis of 15 selected studies to pool data on the association.

Main Results:

  • Significant associations were found between both clinical and histological chorioamnionitis and cerebral palsy.
  • Clinical chorioamnionitis showed a pooled odds ratio of 2.42 (95% CI 1.52-3.84), indicating a 140% increased risk.
  • Histological chorioamnionitis showed a pooled odds ratio of 1.83 (95% CI 1.17-2.89), indicating an 80% increased risk.

Conclusions:

  • Clinical and histological chorioamnionitis are significantly associated with an increased risk of cerebral palsy.
  • Strategies aimed at preventing or reducing chorioamnionitis may lead to a decrease in cerebral palsy incidence.
  • Current diagnostic methods for intrauterine infections require improvement in methodology and speed.