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Updated: Jun 10, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Cavernous lymphangiomas involving bilateral labia minora.
Takashi Watanabe1, Shigeki Matsubara, Takehiko Yamaguchi
1From the Departments of Obstetrics and Gynecology, Pathology, and Plastic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Obstetrics and Gynecology
|July 29, 2010
Summary
Bilateral vulvar lymphangiomas, rare benign tumors, were surgically removed from a 14-year-old girl. Estrogen and progesterone receptor positivity suggests hormonal influence on these lymphatic vessel tumors.
Area of Science:
- Gynecologic Oncology
- Vascular Malformations
- Pediatric Surgery
Background:
- Lymphangiomas are rare benign tumors of lymphatic vessels.
- Vulvar lymphangiomas are exceptionally uncommon, with few reported cases.
- Cavernous lymphangiomas typically affect the labia majora in young women.
Observation:
- A 14-year-old female presented with bilateral labia minora tumors.
- Surgical excision and histological examination confirmed cavernous lymphangioma.
- Immunohistochemistry revealed positive nuclear staining for estrogen and progesterone receptors in stromal fibroblasts.
Findings:
- This case presents bilateral cavernous lymphangiomas of the labia minora, a unique presentation.
- The presence of estrogen and progesterone receptors suggests a potential hormonal influence on tumor development.
- The findings contribute to understanding rare vulvar lymphatic malformations.
Implications:
- Hormonal fluctuations, specifically increased estrogen and progesterone, may play a role in the development of vulvar lymphangiomas.
- Surgical excision followed by cosmetic repair is proposed as the optimal treatment strategy.
- Further research into the hormonal etiology of vulvar lymphangiomas is warranted.
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