Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 10, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Gene expression profiling in breast cancer.

Kiran Turaga1, Geza Acs, Christine Laronga

  • 1Department of Women's Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.

Cancer Control : Journal of the Moffitt Cancer Center
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic impact of somatic mutations among patients with pleural and peritoneal mesothelioma.

NPJ precision oncology·2026
Same author

ASO Author Reflections: Biological Limitations of ctDNA Surveillance in Colon Cancer: The Peritoneal Conundrum.

Annals of surgical oncology·2026
Same author

ASO Visual Abstract: Peritoneal Metastases in Stage II-III Colon Cancer Represent a Blind Spot for Circulating Tumor DNA Surveillance.

Annals of surgical oncology·2026
Same author

Peritoneal Metastases in Stage II-III Colon Cancer Represent a Blind Spot for Circulating Tumor DNA Surveillance.

Annals of surgical oncology·2026
Same author

Evolving therapeutics in colorectal cancer peritoneal metastases.

Cancer metastasis reviews·2026
Same author

Principles of cytoreductive surgery for primary and metastatic peritoneal malignancies-the PSOGI-ESGO-ISSPP Lyon consensus.

The Lancet. Oncology·2026

Molecular assays improve breast cancer treatment by predicting patient outcomes and chemotherapy benefits. These genomic tools are becoming standard practice, offering personalized medicine strategies for better patient care.

Area of Science:

  • Oncology
  • Genomics
  • Personalized Medicine

Background:

  • Breast cancer is a complex disease with diverse subtypes impacting prognosis and treatment response.
  • Molecular assays aim to classify tumors, predict outcomes, and guide personalized treatment strategies.

Purpose of the Study:

  • To provide an overview of the development and application of molecular assays in breast cancer.
  • To discuss the technology, scientific validity, and clinical applicability of these assays.
  • To compare commonly used molecular assays for breast cancer.

Main Methods:

  • Review of the development and application of molecular assays in breast cancer.
  • Discussion of assay technologies and scientific evidence for gene expression profiles.
  • Comparison of three common molecular assays.

Related Experiment Videos

Last Updated: Jun 10, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

Main Results:

  • Molecular assays offer genetic insights for breast cancer treatment planning and outcome assessment.
  • These assays predict prognosis, identifying patients at high or low risk for metastatic disease.
  • The Oncotype DX assay predicts the benefit of chemotherapy in addition to hormone therapy.

Conclusions:

  • Molecular assays are evolving into a standard of practice for breast cancer treatment planning, supported by strong scientific evidence.
  • While their clinical applicability is currently limited to less than half of patients, their potential is vast.
  • Continued research and development promise broader applications in breast cancer management.