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Updated: Jun 10, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Approaches to the study of drug-induced liver injury
1Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. rfontana@med.umich.edu
Abstract:
Retrospective studies of administrative databases have led to highly variable estimates of the incidence and natural history of drug-induced liver injury (DILI) and the agents implicated. In contrast, prospective multicenter registry studies allow for more accurate phenotyping of individual patients with DILI, as well as for collection of biological samples for mechanistic studies. In addition to improved diagnostic and prognostic biomarkers, standardized causality assessment tools are needed, as well as population-based studies that represent the full spectrum of disease severity. This would facilitate further research into the pathogenesis of DILI, leading ultimately to the prevention of this condition.
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