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Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
Published on: April 17, 2012
Size-selective proteolysis on mesoporous silica-based trypsin nanoreactor for low-MW proteome analysis
Qianhao Min1, Ren'an Wu, Liang Zhao
1CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, PR China.
Chemical Communications (Cambridge, England)
|July 29, 2010
Abstract:
In this study, the concept of size-selective proteolysis was first described by using the mesoporous silica-based trypsin nanoreactor. For analysis of a complex protein sample, low-MW proteins were preferentially digested for identification while high-MW proteins were excluded from digestion.
