Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

Expression of ADAMTS4 in Ewing's sarcoma.

K Minobe¹, R Ono, A Matsumine

¹Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu, Japan.

International Journal of Oncology

|July 29, 2010

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discovery of cockroach specimens of the genus Squamoptera (Ectobiidae: Pseudophyllodromiinae) from Okinawa, Japan, showing wing polymorphism.

Tropical biomedicine·2021

Same author

Ecological succession of the microbial communities of an air-conditioning cooling coil in the tropics.

Indoor air·2016

Same author

Usefulness of daily teriparatide treatment in elderly patients over 80 years of age.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2016

Same author

Erratum to: Analysis of daily teriparatide treatment for osteoporosis in men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2015

Same author

The value of the high-sensitivity modified Glasgow prognostic score in predicting the survival of patients with a soft-tissue sarcoma.

The bone & joint journal·2015

Same author

Species clarification of Ogasawara cockroaches which inhabit Japan.

Tropical biomedicine·2015

Researchers identified ADAMTS4 as a potential tumor marker for Ewing sarcoma (EWS). This protein is highly expressed in EWS tumors, offering a new diagnostic possibility for this rare bone cancer.

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Ewing sarcoma (EWS) is a rare bone cancer primarily affecting adolescents.
The EWS-FLI1 fusion gene is the most common genetic driver of EWS.
There is a need for reliable diagnostic markers for EWS.

Purpose of the Study:

To identify novel biological markers for the diagnosis of Ewing sarcoma.
To investigate the role of ADAMTS4 as a potential tumor marker in EWS.

Main Methods:

Retrovirus-mediated signal sequence trap method for marker identification.
Analysis of ADAMTS4 mRNA expression in EWS and other solid tumor samples.
Immunohistochemistry to assess ADAMTS4 protein expression in EWS patient tumors.

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Related Experiment Videos

Last Updated: Jun 10, 2026

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Main Results:

ADAMTS4 mRNA was detected in all examined EWS samples and cell lines.
ADAMTS4 expression was significantly higher in EWS compared to other solid tumors.
ADAMTS4 expression is regulated in an EWS-FLI1 fusion gene-dependent manner.
High levels of ADAMTS4 protein were observed in EWS patient tumor samples.

Conclusions:

ADAMTS4 is a novel and promising tumor marker for Ewing sarcoma.
ADAMTS4 expression is linked to the EWS-FLI1 oncogenic pathway.
Further validation of ADAMTS4 could improve EWS diagnosis and management.