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Updated: Jun 10, 2026

11:17
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
Published on: August 11, 2018
Immunologic response of sarcoidosis
Gernot Zissel1, Antje Prasse, Joachim Müller-Quernheim
1Department of Pneumology, University Hospital Freiburg, Medical Center, Freiburg, Germany.
Seminars in Respiratory and Critical Care Medicine
|July 29, 2010
Summary
Sarcoidosis is a chronic inflammatory disease where immune cells form granulomas. Understanding the immune response is key to managing this complex condition.
Area of Science:
- Immunology
- Pathology
- Genetics
Background:
- Sarcoidosis is a chronic granulomatous disorder.
- Characterized by accumulation of T lymphocytes and macrophages in organs.
- Involves complex interplay of immune cells, cytokines, and chemokines.
Purpose of the Study:
- To discuss the immunological events in sarcoidosis.
- To highlight the role of immune effector cells.
- To explain the induction, evolution, and resolution of granulomatous response.
Main Methods:
- Literature review of immunological events in sarcoidosis.
- Analysis of immune cell involvement.
- Discussion of genetic influences on disease.
Main Results:
- Sarcoidosis pathogenesis involves intricate immune cell interactions.
- Cytokines and chemokines orchestrate granulomatous and fibrotic processes.
- Genetic factors impact susceptibility and disease prognosis.
Conclusions:
- Immune effector cells are critical to sarcoid granulomatous response.
- Further research into immune mechanisms is needed.
- Understanding genetic predispositions may aid in treatment.
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