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Updated: Jun 10, 2026
03:57
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
[Parathyroid hormone injection to counteract delayed bone fractures]
C E Brunnemann1, E C Reisinger, D Ganzer
1Klinik für Innere Medizin II, Universitätsklinikum Rostock.
Deutsche Medizinische Wochenschrift (1946)
|July 29, 2010
Summary
Parathyroid hormone (teriparatide) treatment successfully healed bone fractures that did not respond to conventional methods. This therapy promoted stable bone consolidation in challenging cases of non-union and delayed healing.
Area of Science:
- Orthopedics
- Endocrinology
- Regenerative Medicine
Background:
- Periprosthetic fractures and non-union fractures pose significant treatment challenges.
- Conventional treatments like osteosynthesis, bone-grafting, and revisions often fail to achieve fracture healing.
Observation:
- Three patients (two with periprosthetic femur fractures, one with radius non-union) presented with unhealed fractures.
- Previous surgical interventions had not resulted in fracture consolidation.
Findings:
- Subcutaneous administration of parathyroid hormone (teriparatide) at 20-60 microg daily for 6-10 weeks was initiated.
- All three patients achieved stable bone consolidation following teriparatide treatment.
Implications:
- Parathyroid hormone (teriparatide) demonstrates efficacy in promoting bone healing for recalcitrant fractures.
- This suggests a potential therapeutic role for teriparatide in managing complex orthopedic non-unions and delayed unions.
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