Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
Introduction to Virus01:28

Introduction to Virus

Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
What are Viruses?00:50

What are Viruses?

Overview
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
Bacteriophages of the Human Virome01:23

Bacteriophages of the Human Virome

Bacteriophages are found throughout the human body. They may even outnumber eukaryotic viruses, forming an important and dynamic component of the human virome. Indeed, phages represent the most abundant viral entities, with densities in the gut reaching up to 10⁹ particles per gram of fecal matter, and many belonging to orders such as Caudovirales and Microviridae, while a substantial proportion remains unclassified as viral “dark matter.”Lysogeny and Genetic ExchangeIn the gut, bacteriophages...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces.

bioRxiv : the preprint server for biology·2026
Same author

The EcoCyc database (2025).

EcoSal Plus·2025
Same author

Integrating multiplexed imaging and multiscale modeling identifies tumor phenotype conversion as a critical component of therapeutic T cell efficacy.

Cell systems·2024
Same author

Cross-evaluation of E. coli's operon structures via a whole-cell model suggests alternative cellular benefits for low- versus high-expressing operons.

Cell systems·2024
Same author

Cell biology is….

Cell·2024
Same author

Context-dependent regulation of lipid accumulation in adipocytes by a HIF1α-PPARγ feedback network.

Cell systems·2023
Same journal

Molecular Mechanisms of Cellulase Biosynthesis in Trichoderma reesei: Regulatory Networks, Secretion Pathways, and Environmental Modulation.

Biotechnology journal·2026
Same journal

The Impact of Collection Protocol on the Yield and Purity of Mesenchymal Stem Cell-Derived Extracellular Vesicles Isolated From Serum-Free Media.

Biotechnology journal·2026
Same journal

Biochemical and Functional Characterization of a Novel GH46 Chitosanase for Efficient Chitooligosaccharide Synthesis.

Biotechnology journal·2026
Same journal

LaeA Orchestrates Iron-Heme Supply and P450 Catalytic Efficiency for Enhanced Echinocandin B Biosynthesis in Aspergillus nidulans.

Biotechnology journal·2026
Same journal

Emerging Bioengineering Technologies in Female Reproduction: Preclinical Advances, Translational Challenges, and Future Outlook.

Biotechnology journal·2026
Same journal

Multi-Enzyme Cascade Reaction of Crude Enzyme Strategy for the Economical and Efficient Bioconversion of Rebaudioside A to Rebaudioside M.

Biotechnology journal·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

The virus as metabolic engineer.

Nathaniel D Maynard1, Miriam V Gutschow, Elsa W Birch

  • 1Department of Bioengineering, Stanford University, 318 Campus Drive, Stanford, CA 94305, USA.

Biotechnology Journal
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

Host metabolism is crucial for viral particle production. Metabolic engineers can leverage their unique approaches to develop novel strategies against viral infections by understanding these host-virus metabolic interactions.

More Related Videos

Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly
09:47

Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly

Published on: March 1, 2012

Related Experiment Videos

Last Updated: Jun 10, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly
09:47

Simple and Robust in vivo and in vitro Approach for Studying Virus Assembly

Published on: March 1, 2012

Area of Science:

  • Virology
  • Metabolic Engineering
  • Host-Pathogen Interactions

Background:

  • Genome-wide screens reveal host genetic factors essential for viral replication.
  • Host metabolism plays a critical role in supporting viral particle production.

Purpose of the Study:

  • To review the metabolic aspects of viral infection highlighted by recent studies.
  • To identify opportunities for metabolic engineers to combat viral infections.

Main Methods:

  • Review of recent genome-wide screening studies.
  • Analysis of metabolic requirements for viral production.
  • Comparison of viral infection strategies with metabolic engineering approaches.

Main Results:

  • Host metabolic pathways are critical for efficient viral replication.
  • Viral infection strategies share parallels with metabolic engineering objectives.
  • Metabolic engineers possess unique insights into host-virus dynamics.

Conclusions:

  • Understanding host metabolic requirements offers novel targets for antiviral therapies.
  • Metabolic engineering principles can be applied to develop innovative antiviral strategies.
  • Interdisciplinary approaches combining virology and metabolic engineering hold promise for future antiviral development.